Shelf life (days): 1095.0
Formulation: A solid
Formal Name: ßS-(benzoyl-2,3,4,5,6-d5-amino)-aR-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C47H46D5NO14
Formula Weight: 859.0
CAS Number: 1129540-33-5
Notes: Paclitaxel-d5 contains five deuterium atoms. It is intended for use as an internal standard for the quantification of paclitaxel (Item No. 10461) using GC- or LC-MS. Paclitaxel is cytotoxic against a variety of cancer cell lines with IC50 values ranging from 2.5-7.5 nM.{18505} It disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC50s = 6.7-18.5 nM) at both prophase and G1.{18494} It also initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.{18495}
English
Deutsch
