Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1,1-dioxide-4-hydroxy-2-(methyl-d3)-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C15H10D3N3O4S
Formula Weight: 334.36572
CAS Number: 942047-64-5
Notes: Piroxicam-d3 is intended for use as an internal standard for the quantification of piroxicam (Item No. 13368) by GC- or LC-MS. Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.{17755,7909} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in HEL human erythroleukemic cells (IC50 = 0.45 µM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; Item No. 15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 0.77 µM), which endogenously express COX-2.{7909} Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 240 and ~470 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered at doses of 1, 2.5, and 5 mg/kg.{58296} Formulations containing piroxicam have been used in the treatment of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
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