Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (5R,5aR,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3-methoxy-4,5-bis(methoxy-d3)phenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C22H16D6O8
Formula Weight: 420.44164
Notes: Podophyllotoxin-d6 is intended for use as an internal standard for the quantification of podophyllotoxin (Item No. 19575) and picropodophyllotoxin (Item No. 17329) by GC- or LC-MS. Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.{59991,59992,59993,59994,59995} It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM) and induces mitotic arrest at the G2/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 µg/ml.{59992,59993} Podophyllotoxin (5 µM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells.{59994} It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC50s = 0.0098-0.017 µM).{59995} Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide (Item No. 12092) and teniposide (Item No. 14425).{31220} Formulations containing podophyllotoxin have been used in the treatment of external genital warts.
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