Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-(((S)-2-(methyl-d3)butanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate, monosodium salt
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C23H32D3O7 / Na
Formula Weight: 449.52775
CAS Number: 1329836-90-9
Notes: Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin (Item No. 10010343) by GC- or LC-MS. Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312} In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.
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