Shelf life (days): 730.0
Formulation: A solution in acetonitrile
Formal Name: 9-oxo-11a,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid,1-glyceryl ester-d5
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C23H33D5O7
Formula Weight: 431.6
Notes: Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceryl ester-d5) is intended for use as an internal standard for the quantification of PGE2-1-glyceryl ester by GC- or LC-MS. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the central cannabinoid receptor.{4614,5306} Incubation of 2-AG with cyclooxygenase-2 and specific PGH2 isomerases in cell cultures and isolated enzyme preparations results in PG glycerol ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.{10555}
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