Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-d3-pyridinium, monobromide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C9H10D3N2O2 / Br
Formula Weight: 264.13398
Notes: Pyridostigmine-d3 is intended for use as an internal standard for the quantification of pyridostigmine (Item No. 23831) by GC- or LC-MS. Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes).{38659} Pyridostigmine (10 µM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells.{38660} It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner.{38661} Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation.{38662} Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
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