Shelf life (days): 730.0
Formulation: A solution in methyl acetate
Formal Name: 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl-2,3,4,5,6,7,8-d7)-2H-pyran-2-one
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C16H6BrD7O2
Formula Weight: 324.2
Notes: (R)-Bromoenol lactone-d7 ((R)-BEL-d7) is intended for use as an internal standard for the quantification of (R)-BEL by GC- or LC-MS. The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipase A2 (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2γ. Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.{12978} (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.
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