Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-4,5,6,7-d4, monosodium salt
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C18H16D4N3O3S / Na
Formula Weight: 385.44983
Notes: Rabeprazole-d4 is intended for use as an internal standard for the quantification of rabeprazole (Item No. 14939) by GC- or LC-MS. Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM).{23855} It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole (Item No. 14880), lansoprazole (Item No. 13627), and pantoprazole (Item No. 21345).{23854} Rabeprazole (30 mg/kg) inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula.{47042} It also inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 μg/mL).{23854} Formulations containing rabeprazole have been used in the treatment of ulcers, pathological hypersecretory conditions, and gastroesophageal reflux disease (GERD).
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