Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(4-chlorobenzamido-2,3,5,6-d4)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C19H11ClD4N2O4
Formula Weight: 374.81042
CAS Number: 1219409-06-9
Notes: Rebamipide-d4 is intended for use as an internal standard for the quantification of rebamipide (Item No. 17186) by GC- or LC-MS. Rebamipide is a gastroprotective agent and mucin secretagogue.{61256,61258} It increases the levels of prostaglandin E2 (PGE2; Item No. 14010) and COX-2 in rat gastric mucosa when administered at doses of 15 and 50 mg/kg per day. Rebamipide (30 and 100 mg/kg, i.p.) prevents the formation of gastric ulcers induced by absolute ethanol, sodium hydroxide, or hydrochloric acid in rats, an effect that can be blocked by the non-selective COX inhibitor indomethacin (Item No. 70270).{61257} It also increases the production of mucin 16 in stratified corneal epithelial cells in vitro when used at concentrations of 10 and 100 µM.{61258} Rebamipide (1% w/v) increases the levels of mucin-like substances in rabbit conjunctiva and cornea and, in a rabbit model of dry eye disease, reduces desiccation-induced corneal damage.{61259} Formulations containing rebamipide have been used in the treatment of peptic ulcer disease and dry eye disease.
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