Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-di(methyl-d3)phenyl]amino]-2-pyrimidinyl]amino]-benzonitrile, monohydrochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C22H12D6N6 / HCl
Formula Weight: 408.9
Notes: Rilpivirine-d6 is intended for use as an internal standard for the quantification of rilpivirine (Item No. 21559) by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM.{35241} It is active against NNRTI-resistant HIV strains with EC50 values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Item No. 18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.{35242}
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