Shelf life (days): 1460.0
Formulation: A solid
Formal Name: thiazol-5-ylmethyl ((2S,3S,5S)-3-hydroxy-5-((S)-3-methyl-2-(3-methyl-3-((2-(propan-2-yl-1,1,1,3,3,3-d6)thiazol-4-yl)methyl)ureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C37H42D6N6O5S2
Formula Weight: 726.98282
CAS Number: 1217720-20-1
Notes: Ritonavir-d6 is intended for use as an internal standard for the quantification of ritonavir (Item No. 13872) by GC- or LC-MS. Ritonavir is an HIV protease inhibitor.{24746} It inhibits recombinant HIV-1 protease by 79% when used at a concentration of 0.5 nM. It inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM) as well as cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively).{24746,26076} Ritonavir also inhibits the cytochrome P450 (CYP) isoform CYP3A (IC50 = 0.14 μM).{24198} It inhibits CYP-mediated oxidative metabolism of the HIV protease inhibitors saquinavir (Item No. 9001893), indinavir (Item No. 15150), nelfinavir (Item No. 15144), and amprenavir (Item No. 15369) in rat and human liver microsomes in a concentration-dependent manner.{42447} Ritonavir (10 mg/kg) also prevents decreases in plasma levels of these four compounds in rats. Formulations containing ritonavir have been used in the treatment of HIV-1 infection.
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