Shelf life (days): 730.0
Formulation: A solution in methyl acetate
Formal Name: 6E-(bromoethylene)tetrahydro-3S-(1-naphthalenyl-2,3,4,5,6,7,8-d7)-2H-pyran-2-one
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C16H6BrD7O2
Formula Weight: 324.2
Notes: (S)-Bromoenol lactone-d7 ((S)-BEL-d7) is intended for use as an internal standard for the quantification of (S)-BEL by GC- or LC-MS. The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipase A2 (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2β that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.{12978} (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.
English
Deutsch
