Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl-3,3,4,4,4-d5]phenoxy]-N,N-dimethyl-ethanamine
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C26H24D5NO
Formula Weight: 376.6
CAS Number: 157698-32-3
Notes: Tamoxifen-d5 is intended for use as an internal standard for the quantification of tamoxifen (Item No. 13258) by GC- or LC-MS. Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor).{54811} It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM.{51321} Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively).{51322} It decreases tumor proliferation, weight, and volume in an MCF-7 mouse xenograft model when administered at a dose of 100 µg/animal per day.{46077} Tamoxifen (0.8 mg/kg every two weeks) also reduces proteinuria and increases survival in an NZBWF1 mouse model of systemic lupus erythematosus (SLE).{53541} It can be used as a regulator for Cre-recombinase inducible gene expression in vivo.{51320} Formulations containing tamoxifen have been used in the treatment of estrogen receptor-positive breast cancer.
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