Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-amino-ethane-1,1,2,2-d4-sulfonic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C2H3D4NO3S
Formula Weight: 129.17216
CAS Number: 342611-14-7
Notes: Taurine-d4 is intended for use as an internal standard for the quantification of taurine (Item No. 27031) by GC- or LC-MS. Taurine is a sulfur-containing amino acid produced endogenously and also ingested in the diet.{43869} It is ubiquitously present in most cells and has diverse biological activities, including antioxidative, anticancer, cardioprotective, and neuroprotective properties.{43869,43870,43871,14507} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at concentrations ranging from 125 to 1,000 µg/ml and decreases the viability of MCF-7 and MDA-MB-231 human breast cancer cells.{43870} It prevents left ventricular dysfunction in the mdx mouse model of late-stage Duchenne muscular dystrophy when administered at a dose of 1 g/kg per day for six months.{43871} Taurine (100 µM) prevents neurotoxicity induced by amyloid-β (Aβ) or the glutamate receptor agonists glutamate, NMDA (Item No. 14581), or kainic acid (Item No. 78050) in chick embryonic retinal neurons, an effect that can be blocked by the GABAA receptor antagonist picrotoxin (Item No. 20771).{14507}
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