Shelf life (days): 1460.0
Formulation: A solid
Formal Name: a-[2-(4-chlorophenyl)ethyl]-a-(1,1-dimethylethyl-d9)-1H-1,2,4-triazole-1-ethanol
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C16H13ClD9N3O
Formula Weight: 316.87274
CAS Number: 1246818-83-6
Notes: Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole (Item No. 24052) by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi.{42004} It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively.{30331} It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay.{42005} Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses.{42006} It has a feminizing effect on male pups and a virilizing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning the platform location in the Morris water maze.{42007} Formulations containing tebuconazole have been used as preservatives for wood and other materials, as well as fungicides in agricultural, commercial, industrial, and residential areas.
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