Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (5R)-3-[3-fluoro-4-[6-[2-(methyl-13C-d3)-2H-tetrazol-5-yl]-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C16[13C]H12D3FN6O3
Formula Weight: 374.4
CAS Number: 2931763-72-1
Notes: Tedizolid-13C-d3 is intended for use as an internal standard for the quantification of tedizolid (Item No. 32952) by GC- or LC-MS. Tedizolid is an oxazolidinone antibiotic and active metabolite of the antibiotic tedizolid phosphate (Item No. 23729).{59752} Tedizolid phosphate is converted to tedizolid by phosphatases in vivo. It is active against a wide variety of clinical isolates, including isolates of methicillin-resistant S. aureus (MRSA), E. faecalis, and penicillin-susceptible S. pneumoniae (MICs = 0.5, 0.5, and 0.25 µg/ml, respectively), as well as isolates of anaerobic bacteria (MICs = 0.25-4 µg/ml). Tedizolid protects against mortality in a mouse model of systemic methicillin-susceptible S. aureus (MSSA) infection (ED50 = 8.8 mg/kg).{59753}
English
Deutsch
