Shelf life (days): 1460.0
Formulation: A solid
Formal Name: P-[[1-[(6-amino-9H-purin-9-yl)methyl-d2]ethoxy-1,2,2,2-d4]methyl]-phosphonic acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C9H8D6N5O4P
Formula Weight: 293.3
CAS Number: 1020719-94-1
Notes: Tenofovir-d6 is intended for use as an internal standard for the quantification of tenofovir (Item No. 13874) by GC- or LC-MS. Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.
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