Shelf life (days): 1460.0
Formulation: A solid
Formal Name: rel-1,3R,4,6,7,11bR-hexahydro-9,10-dimethoxy-3-(2-(methyl-d3)propyl-2,3,3,3-d4)-2H-benzo[a]quinolizin-2-one
Purity: ≥99% (deuterated forms (d1-d7)
Formula Markup: C19H20D7NO3
Formula Weight: 324.46504
CAS Number: 2701977-99-1
Notes: Tetrabenazine-d7 is intended for use as an internal standard for the quantification of tetrabenazine (Item No. 20380) by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay).{26973} It dose-dependently reduces levels of the monoamines norepinephrine (Item No. 16673), dopamine (Item No. 21992), and serotonin (5-HT; Item No. 14332) in rat brain and has been used to induce depressive-like behavior in animal models.{47227,47228} Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease.{47229} Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease.
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