Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,2'-thiobis(acetic-2,2,2',2'-d4 acid)
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C4H2D4O4S
Formula Weight: 154.2
CAS Number: 132090-51-8
Notes: Thiodiglycolic acid-d4 (TDGA-d4) contains four deuterium atoms at the 2, 2, 2’, and 2’ positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.{30000} Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.{29999} Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.{29999}
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