Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,3:4,5-bis-O-[1-(methyl-d3)ethylidene-2,2,2-d3]-ß-D-fructopyranose, 1-sulfamate
Purity: ≥99% deuterated forms (d1-d12)
Formula Markup: C12H9D12NO8S
Formula Weight: 351.4358
CAS Number: 1279037-95-4
Notes: Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.
English
Deutsch
