Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-(3,5-dimethoxy-4-(methoxy-d3)benzyl)pyrimidine-2,4-diamine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C14H15D3N4O3
Formula Weight: 293.33606
CAS Number: 1189923-38-3
Notes: Trimethoprim-d3 is intended for use as an internal standard for the quantification of trimethoprim (Item No. 16473) by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.{27030,27031} Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).{27031} Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.
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