RG108, CAS 48208-26-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: aS-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1H-indole-3-propanoic acid

Purity: ≥98%

Formula Markup: C19H14N2O4

Formula Weight: 334.3

CAS Number: 48208-26-0

Notes: DNA methylation regulates gene expression in normal and malignant cells. RG108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro).{17258} It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine.{17257,17258} Further, RG108 inhibits DNA methyltransferase activity by blocking the enzyme active site.{17257} Through these actions, RG108 demethylates and reactivates epigenetically silenced tumor suppressor genes.{17258}

• SKU: CAY13302-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13302-50
• Package Unit: 50 mg
• Quantity Unit: STK