Rheb inhibitor NR1, CAS 2216763-38-9

Product Description: Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1?μM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1].(Rheb-IVK: Rheb-dependent mTORC1 kinase activity)

Applications: Cancer-Kinase/protease

Formula: C25H19BrCl2N2O3S

References: [1]Mahoney SJ, et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548.

CAS Number: 2216763-38-9

Molecular Weight: 578.30

Compound Purity: 99.03

Research Area: Cancer; Inflammation/Immunology; Neurological Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: mTOR

• SKU: MEXHY-124798-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-124798-50
• Package Unit: 50 mg
• Quantity Unit: STK