Product Description: RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
Applications: Cancer-programmed cell death
Formula: C21H26Cl2N4O2
References: [1]Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073.
CAS Number: 2172651-73-7
Molecular Weight: 437.36
Compound Purity: 99.56
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Phosphatase;SHP2