RMC-6291, CAS 2641998-63-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (3S)-N1-[N-[[1-[4-(dimethylamino)-4-methyl-1-oxo-2-pentyn-1-yl]-4-fluoro-4-piperidinyl]carbonyl]-N-methyl-L-valyl-3-[4-[(2R)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-3-pyridinyl]-1H-indol-5-yl]-2-morpholinyl]-L-alanyl]hexahydro-3-pyridazinecarboxylic acid, (3?2)-lactone

Purity: ≥98%

Formula Markup: C55H78FN9O8

Formula Weight: 1012.262083

CAS Number: 2641998-63-0

Notes: A covalent KRASG12C inhibitor; binds to KRASG12C and prevents KRASG12C-induced signaling via recruitment of PPIase A; decreases the proliferation of 15 cancer cell lines expressing KRASG12C (median EC50 = 0.11 nM); induces apoptosis in NCI H358 cells; reduces tumor volume in an NCI H358 mouse xenograft model at 10-200 mg/kg per day

• SKU: CAY42174-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42174-5
• Package Unit: 5 mg
• Quantity Unit: STK