Product Description: RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively[1].
Applications: Cancer-programmed cell death
Formula: C22H20F5N3O3
References: [1]Luistro L, et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res. 2009, 69(19), 7672-7680./[2]Debeb BG, et al. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012./[3]Huynh C, et al. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One. 2011, 6(9), e25264.
CAS Number: 847925-91-1
Molecular Weight: 469.40
Compound Purity: 99.01
Research Area: Neurological Disease; Cancer
Solubility: DMSO : ≥ 49 mg/mL
Target: Notch;γ-secretase
English
Deutsch
