RO4987655, CAS 874101-00-5

Product Description: RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.

Applications: Cancer-Kinase/protease

Formula: C20H19F3IN3O5

References: [1]Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15(23):7368-74./[2]Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4(1):34.

CAS Number: 874101-00-5

Molecular Weight: 565.28

Compound Purity: 99.26

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: MEK

• SKU: MEXHY-14719-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-14719-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK