Product Description: RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C13H18N2O
References: [1]Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470./[2]Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56./[3]Barnes DA, et al. TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages. J Neuroimmune Pharmacol. 2023 Jun;18(1-2):100-111.
CAS Number: 1043495-96-0
Molecular Weight: 218.3
Compound Purity: 98.75
Research Area: Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Trace Amine-associated Receptor (TAAR)
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