Rofecoxib, CAS 162011-90-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone

Purity: ≥98%

Formula Markup: C17H14O4S

Formula Weight: 314.4

CAS Number: 162011-90-7

Notes: Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2 over COX-1 with IC50 values of 0.018 and >15 µM, respectively, for production of prostaglandin E2 (PGE2; Item No. 14010) in CHO cells expressing the recombinant human enzymes.{12018} In vivo, rofecoxib inhibits carrageenan-induced paw edema and hyperalgesia (ID50s = 1.5 and 1.0 mg/kg, respectively), LPS-induced pyresis (ID50 = 0.24 mg/kg), and M. butyricum-induced arthritis (ID50 = 0.74 mg/kg/day per day) in rats. Formulations containing rofecoxib were previously used in the treatment of pain and arthritis.

• SKU: CAY10010260-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10010260-500
• Package Unit: 500 mg
• Quantity Unit: STK