Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[4-(methylsulfonyl)phenyl]-3-(phenyl-d5)-2(5H)-furanone
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C17H9D5O4S
Formula Weight: 319.38696
CAS Number: 544684-93-7
Notes: Rofecoxib-d5 is intended for use as an internal standard for the quantification of rofecoxib (Item No. 10010260) by GC- or LC-MS. Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2 over COX-1 with IC50 values of 0.018 and >15 µM, respectively, for production of prostaglandin E2 (PGE2; Item No. 14010) in CHO cells expressing the recombinant human enzymes.{12018} In vivo, rofecoxib inhibits carrageenan-induced paw edema and hyperalgesia (ID50s = 1.5 and 1.0 mg/kg, respectively), LPS-induced pyresis (ID50 = 0.24 mg/kg), and M. butyricum-induced arthritis (ID50 = 0.74 mg/kg per day) in rats. Formulations containing rofecoxib were previously used in the treatment of pain and arthritis.
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