Product Description: Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2].
Applications: Neuroscience-Neurodegeneration
Formula: C16H25ClN2O
References: [1]Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54./[2]Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93.
CAS Number: 91374-20-8
Molecular Weight: 296.84
Compound Purity: 99.85
Research Area: Neurological Disease
Solubility: DMSO : 16.67 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Dopamine Receptor
English
Deutsch
