RP 6685, CAS 2832047-80-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[3-(6-amino-3-pyridazinyl)-2-propyn-1-yl]-N-(4-fluorophenyl)-3,5-bis(trifluoromethyl)-2-pyridineacetamide

Purity: ≥98%

Formula Markup: C22H14F7N5O

Formula Weight: 497.4

CAS Number: 2832047-80-8

Notes: A DNA polymerase θ inhibitor (IC50 = 0.55 nM); selective for DNA polymerase θ over DNA polymerase α, -ε, -γ, and -ν (IC50s = >100 µM for all); inhibits double-strand break repair in AAVS1 loci in HCT116 cells (IC50 = 0.5 µM) and the proliferation of HCT116 BRCA2-/- cells (IC50 = 0.32 µM); reduces tumor volume in an HCT116 BRCA2-/- mouse xenograft model

• SKU: CAY42127-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42127-5
• Package Unit: 5 mg
• Quantity Unit: STK