RP-6685, CAS 2832047-80-8

Product Description: RP-6685 is a potent, selective and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 shows antitumor efficacy in mouse tumor xenograft model[1]. RP-6685 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C22H14F7N5O

References: [1]Bubenik M, et al. Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ. J Med Chem. 2022 Sep 20.

CAS Number: 2832047-80-8

Molecular Weight: 497.37

Compound Purity: 99.96

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: DNA/RNA Synthesis

• SKU: MEXHY-151462-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-151462-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK