RX-3117, CAS 865838-26-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]- 2(1H)-pyrimidinone

Purity: ≥95%

Formula Markup: C10H12FN3O4

Formula Weight: 257.2

CAS Number: 865838-26-2

Notes: RX-3177 is a nucleoside derivative and an anticancer agent.{51913} It is cytotoxic to HCT116 colorectal, MDA-MB-231 breast, PANC-1 pancreatic, A549 lung, and U251 brain cancer cells (IC50s = 0.39, 0.18, 0.62, 0.34, and 0.83 µM, respectively). RX-3177 (1 and 10 µM) induces DNA damage and apoptosis in A2780 ovarian cancer cells. In vivo, RX-3177 (50-500 mg/kg) reduces mean tumor volume in HCT116, HT-29, Caki-1, MIA PaCa-2, and BxPC-3 mouse xenograft models.{51912}

• SKU: CAY27922-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27922-1
• Package Unit: 1 mg
• Quantity Unit: STK