(S)-Crizotinib, CAS 1374356-45-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Purity: ≥98%

Formula Markup: C21H22Cl2FN5O

Formula Weight: 450.336283

CAS Number: 1374356-45-2

Notes: (S)-Crizotinib is an inhibitor of muT homolog 1 (MTH1; IC50 = 72 nM).{28959} It is selective for MTH1 over a panel of 456 kinases at 1 µM. (S)-Crizotinib (30 µM) induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 human gastric cancer cells.{59217} It inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras and p53 (IC50s = 0.52-7.4 µM).{28959} (S)-Crizotinib (25 mg/kg, s.c.) reduces tumor growth in an SW480 mouse xenograft model.{28959}

• SKU: CAY31114-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31114-5
• Package Unit: 5 mg
• Quantity Unit: STK