(S)-MG115, CAS 133407-86-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-L-leucinamide

Purity: ≥95%

Formula Markup: C25H39N3O5

Formula Weight: 461.6

CAS Number: 133407-86-0

Notes: (S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM).{13817} It reduces the degradation of ubiquitin-conjugated proteins in extracts.{13817} (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53.{13817,25785,13815} Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.{13815,25786,25784}

• SKU: CAY15413-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15413-10
• Package Unit: 10 mg
• Quantity Unit: STK