(S,R,S)-AHPC-Me, CAS 1948273-02-6

Description: (S,R,S)-AHPC-Me is a VHL ligand based on (S,R,S)-AHPC that can be used to recruit von Hippel-Lindau (VHL) proteins. It efficiently degrades BET proteins in desmoplasia-resistant prostate cancer cells with a DC50 < 1 nM, and it can be used to synthesize ARV-771.

CAS Number: 1948273-02-6

Formula: C23H32N4O3S

Molecular Weight: 444,59

References: Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.

• SKU: TGMT7752-25mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T7752-25mg
• Package Unit: 25 mg
• Quantity Unit: STK