Product Description: S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2].
Applications: Cancer-Kinase/protease
Formula: C22H21NO2S
References: [1]Wei Wu, et al. S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma. Oncol Lett. 2018 Jul;16(1):1023-1030. /[2]Salvatore DeBonis, et al. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther. 2004 Sep;3(9):1079-90.
CAS Number: 2799-07-7
Molecular Weight: 363.47
Compound Purity: 99.31
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Apoptosis;Kinesin
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