S1RA, CAS 878141-96-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine

Purity: ≥98%

Formula Markup: C20H23N3O2

Formula Weight: 337.4

CAS Number: 878141-96-9

Notes: S1RA is a sigma-1 (σ1) receptor antagonist (Ki = 17 nM).{27984} It is selective for σ1 receptors over σ2 receptors (Ki = 9,300 nM), as well as a panel of 170 additional receptors at 1 µM. S1RA reduces capsaicin-induced mechanical allodynia, formalin-induced licking and biting behavior, and partial sciatic nerve ligation-induced thermal hyperalgesia in mice (ED50s = 26.3, 43.7, and 18.8 mg/kg, respectively). It also enhances fentanyl- or loperamide-induced analgesia without affecting gastrointestinal transit in mice.{27986}

• SKU: CAY16279-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16279-500
• Package Unit: 500 µg
• Quantity Unit: STK