Safotibant, CAS 633698-99-4

Product Description: Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model[1][2].

Applications: COVID-19-immunoregulation

Formula: C25H34N4O5S

References: [1]Sevcik MA, et al., Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model. J Pain. 2005 Nov;6(11):771-5. /[2]Pouliot M, et al., Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats. PLoS One. 2012;7(3):e33864.

CAS Number: 633698-99-4

Molecular Weight: 502.63

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Bradykinin Receptor

• SKU: MEXHY-100827-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100827-1
• Package Unit: 1 mg
• Quantity Unit: STK