Samuraciclib hydrochloride, CAS 1805789-54-1

Description: Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold higher than CDK1, CDK2 (IC50 is 578 nM), CDK5 and CDK9 respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 μM. Samuraciclib hydrochloride has anti-tumor effects.

CAS Number: 1805789-54-1

Formula: C22H31ClN6O

Molecular Weight: 430,97

References: Patel H, et al. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. Mol Cancer Ther. 2018 Jun;17(6):1156-1166.

• SKU: TGMT10898-1mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T10898-1mg
• Package Unit: 1 mg
• Quantity Unit: STK