Product Description: Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Applications: Cancer-programmed cell death
Formula: C11H16Cl2N6
Citations: bioRxiv. 2024 August 26./Cell. 2020 Jun 11;181(6):1329-1345.e24./mSystems. 2024 Apr 2:e0024624./Sci Adv. 2023 May 19;9(20):eade0718./SSRN. 2024 Mar 14.
References: [1]Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7./[2]Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.
CAS Number: 138794-73-7
Molecular Weight: 303.19
Compound Purity: 99.76
Research Area: Cancer
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 3.85 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Others
English
Deutsch
