SB 202190 (hydrochloride) (Standard), CAS 350228-36-3

Product Description: SB 202190 (hydrochloride) (Standard) is the analytical standard of SB 202190 (hydrochloride). This product is intended for research and analytical applications. SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3].

Formula: C20H15ClFN3O

References: [1]Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105./[2]Yang S, et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Res Int. 2013;2013:215798.

CAS Number: 350228-36-3

Molecular Weight: 367.80

Research Area: Cancer; Neurological Disease

Target: Apoptosis;Autophagy;Organoid;p38 MAPK;Reference Standards

• SKU: MEXHY-10295AR-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10295AR-0
• Package Unit: Get quote
• Quantity Unit: STK