Product Description: SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C21H19ClN4O2
Citations: Authorea. September 19, 2022./Biochem Biophys Res Commun. 2024 May 23:722:150074./Neuroendocrinology. 2024 May 8./Brain. 2024 May 3:awae143.
References: [1]Kennett GA, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. /[2]Harmon JL, et al. 5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. J Pharmacol Exp Ther. 2016 Apr;357(1):1-9. /[3]Kennett GA, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
CAS Number: 181632-25-7
Molecular Weight: 394.85
Compound Purity: 99.88
Research Area: Metabolic Disease; Neurological Disease
Solubility: DMSO : ≥ 44 mg/mL
Target: 5-HT Receptor
English
Deutsch
