SB 297006, CAS 58816-69-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-benzoyl-4-nitro-L-phenylalanine, ethyl ester

Purity: ≥99%

Formula Markup: C18H18N2O5

Formula Weight: 342.4

CAS Number: 58816-69-6

Notes: SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.{32621} It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells.{32621} It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).{32620}

• SKU: CAY11964-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11964-5
• Package Unit: 5 mg
• Quantity Unit: STK