Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane
Purity: ≥95%
Formula Markup: C15H14O3S2
Formula Weight: 306.4
CAS Number: 292605-14-2
Notes: SB-3CT is a selective, mechanism-based inhibitor of the gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9 (Kis = 28 and 400 nM, respectively).{26759,26757} First pass metabolism of SB-3CT in vivo produces a monohydroxylated metabolite that has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively).{26757} Both SB-3CT and its active metabolite can cross the blood-brain barrier and have utility in diseases of the central nervous system, such as stroke and traumatic brain injury.{26757,26758} SB-3CT may have applications in other pathologies involving gelatinases, including cancer, cardiovascular diseases, and inflammation.{26760,26756}
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