SBP-7455, CAS 1884222-74-5

Product Description: SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1].

Applications: COVID-19-immunoregulation

Formula: C16H17F3N4O2

References: [1]Huiyu Ren, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020 Dec 10;63(23):14609-14625

CAS Number: 1884222-74-5

Molecular Weight: 354.33

Compound Purity: 98.24

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Autophagy;ULK

• SKU: MEXHY-137742-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-137742-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK