SC-43, CAS 1400989-25-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[3-(4-cyanophenoxy)phenyl]-urea

Purity: ≥98%

Formula Markup: C21H13ClF3N3O2

Formula Weight: 431.794849

CAS Number: 1400989-25-4

Notes: SC-43 is an activator of Src homology region 2 domain-containing phosphatase 1 (SHP-1).{60794} It activates SHP-1 phosphatase activity in a cell-free assay and inhibits IL-6-induced phosphorylation of STAT3 in PLC/PRF/5 hepatocellular carcinoma cells when used at a concentration of 10 µM. SC-43 inhibits the proliferation of PLC/PRF/5 cells (IC50 = 0.5 µM). It decreases disease severity and improves survival in a mouse model of carbon tetrachloride-induced liver fibrosis when administered at doses of 10 and 20 mg/kg.{60795}

• SKU: CAY34874-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34874-1
• Package Unit: 1 mg
• Quantity Unit: STK