Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2E,6E-bis(4-pyridinylmethylene)-cyclohexanone
Purity: ≥98%
Formula Markup: C18H16N2O
Formula Weight: 276.3
CAS Number: 871361-88-5
Notes: Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2).{13740} Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer.{15097} Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt.{19437} At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death.{19437} In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.{19437}
English
Deutsch
