Product Description: SC209 (3-Aminophenyl Hemiasterlin) is a 3-aminophenyl hemiasterlin derivative that serves as a cytotoxin for ADCs, targeting tubulin. SC209 has reduced potential for drug efflux via P-glycoprotein 1 drug pump compared with other tubulin-targeting payloads. SC209 exhibits antitumor activity and can be used in the synthesis of ADC molecules[1][2].
Applications: Cancer-programmed cell death
Formula: C27H44N4O4
References: [1]Alice Yam, et al. Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof. Patent. WO2021247798. 2021-12-09./[2]De Almeida V, et al. Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer. Gynecologic Oncology, 2018, 149: 50.
CAS Number: 1977557-86-0
Molecular Weight: 488.66
Compound Purity: 99.52
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: ADC Cytotoxin;Microtubule/Tubulin;P-glycoprotein
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